Cargando…
Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway
Squamous cell carcinomas (SCC) frequently have an exceptionally high mutational burden. As consequence, they rapidly develop resistance to platinum-based chemotherapy and overall survival is limited. Novel therapeutic strategies are therefore urgently required. SCC express ∆Np63, which regulates the...
Autores principales: | Prieto-Garcia, Cristian, Hartmann, Oliver, Reissland, Michaela, Fischer, Thomas, Maier, Carina R., Rosenfeldt, Mathias, Schülein-Völk, Christina, Klann, Kevin, Kalb, Reinhard, Dikic, Ivan, Münch, Christian, Diefenbacher, Markus E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901929/ https://www.ncbi.nlm.nih.gov/pubmed/34611298 http://dx.doi.org/10.1038/s41418-021-00875-z |
Ejemplares similares
-
USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K
por: Prieto‐Garcia, Cristian, et al.
Publicado: (2022) -
Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells
por: Prieto‐Garcia, Cristian, et al.
Publicado: (2020) -
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer
por: Maier, Carina R., et al.
Publicado: (2023) -
USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma
por: Prieto-Garcia, Cristian, et al.
Publicado: (2021) -
PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy
por: Fischer, Thomas, et al.
Publicado: (2022)