Cargando…

Spatially Annotated Single Cell Sequencing for Unraveling Intratumor Heterogeneity

Intratumor heterogeneity is a major obstacle to effective cancer treatment. Current methods to study intratumor heterogeneity using single-cell RNA sequencing (scRNA-seq) lack information on the spatial organization of cells. While state-of-the art spatial transcriptomics methods capture the spatial...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smit, Myrthe M., Feller, Kate J., You, Li, Storteboom, Jelle, Begce, Yasin, Beerens, Cecile, Chien, Miao-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902076/ https://www.ncbi.nlm.nih.gov/pubmed/35273957 http://dx.doi.org/10.3389/fbioe.2022.829509

Ejemplares similares

Protocol for profiling in vitro intratumor heterogeneity using spatially annotated single-cell sequencing
por: Smit, Myrthe M., et al.
Publicado: (2023)

Instant processing of large-scale image data with FACT, a real-time cell segmentation and tracking algorithm
por: Chou, Ting-Chun, et al.
Publicado: (2023)

Spatial Assessment of Heterogeneous Tissue Natural Frequency Using Micro-Force Optical Coherence Elastography
por: Lan, Gongpu, et al.
Publicado: (2022)

Unraveling the mechanobiology of cornea: From bench side to the clinic
por: Yang, Shu, et al.
Publicado: (2022)

Enhanced Acylcarnitine Annotation in High-Resolution Mass Spectrometry Data: Fragmentation Analysis for the Classification and Annotation of Acylcarnitines
por: van der Hooft, Justin J. J., et al.
Publicado: (2015)

Innovative Tools for Mechanobiology: Unraveling Outside-In and Inside-Out Mechanotransduction
por: Mohammed, Danahe, et al.
Publicado: (2019)

Treatment of Hepatocellular Carcinoma by Intratumoral Injection of (125)I-AA98 mAb and Its Efficacy Assessments by Molecular Imaging
por: Zhou, Jun, et al.
Publicado: (2019)

Unraveling the Complex Interplay of Fis and IHF Through Synthetic Promoter Engineering
por: Monteiro, Lummy Maria Oliveira, et al.
Publicado: (2020)

Unraveling the Local Relation Between Tissue Composition and Human Brain Mechanics Through Machine Learning
por: Linka, Kevin, et al.
Publicado: (2021)

Identifying Acetylation Protein by Fusing Its PseAAC and Functional Domain Annotation
por: Qiu, Wang-Ren, et al.
Publicado: (2019)

Improved understanding of biorisk for research involving microbial modification using annotated sequences of concern
por: Godbold, Gene D., et al.
Publicado: (2023)

Spatial Manipulation with Microfluidics
por: Lin, Benjamin, et al.
Publicado: (2015)

Analysis of intratumor heterogeneity unravels lung cancer evolution
por: de Bruin, Elza C, et al.
Publicado: (2015)

Unraveling the Molecular Signature of Extracellular Vesicles From Endometrial-Derived Mesenchymal Stem Cells: Potential Modulatory Effects and Therapeutic Applications
por: Marinaro, Federica, et al.
Publicado: (2019)

Heterogeneity of Alkane Chain Length in Freshwater and Marine Cyanobacteria
por: Shakeel, Tabinda, et al.
Publicado: (2015)

Mechanobiology of Epithelia From the Perspective of Extracellular Matrix Heterogeneity
por: Kozyrina, Aleksandra N., et al.
Publicado: (2020)

Isolation and Investigation of Natural Rare Earth Metal Chelating Agents From Calothrix brevissima - A Step Towards Unraveling the Mechanisms of Metal Biosorption
por: Jurkowski, Wojciech, et al.
Publicado: (2022)

Characterizing Glioblastoma Heterogeneity via Single-Cell Receptor Quantification
por: Chen, Si, et al.
Publicado: (2018)

In vitro Characteristics of Heterogeneous Equine Hoof Progenitor Cell Isolates
por: Yang, Qingqiu, et al.
Publicado: (2019)

Texture Synthesis Based Thyroid Nodule Detection From Medical Ultrasound Images: Interpreting and Suppressing the Adversarial Effect of In-place Manual Annotation
por: Yao, Siqiong, et al.
Publicado: (2020)

A Bayesian Framework That Integrates Heterogeneous Data for Inferring Gene Regulatory Networks
por: Santra, Tapesh
Publicado: (2014)

A Subdomain Method for Mapping the Heterogeneous Mechanical Properties of the Human Posterior Sclera
por: Kollech, Hirut G., et al.
Publicado: (2019)

The Study of Sarcoma Microenvironment Heterogeneity Associated With Prognosis Based on an Immunogenomic Landscape Analysis
por: Deng, Jin, et al.
Publicado: (2020)

Inferring lncRNA Functional Similarity Based on Integrating Heterogeneous Network Data
por: Li, Jianwei, et al.
Publicado: (2020)

Agent-Based Models Predict Emergent Behavior of Heterogeneous Cell Populations in Dynamic Microenvironments
por: Yu, Jessica S., et al.
Publicado: (2020)

Heterogeneous Graph Convolutional Networks and Matrix Completion for miRNA-Disease Association Prediction
por: Zhu, Rongxiang, et al.
Publicado: (2020)

Intravital Metabolic Autofluorescence Imaging Captures Macrophage Heterogeneity Across Normal and Cancerous Tissue
por: Heaster, Tiffany M., et al.
Publicado: (2021)

Deciphering the Potential of Rhizobium pusense MB-17a, a Plant Growth-Promoting Root Endophyte, and Functional Annotation of the Genes Involved in the Metabolic Pathway
por: Chaudhary, Twinkle, et al.
Publicado: (2021)

SCAU-Net: Spatial-Channel Attention U-Net for Gland Segmentation
por: Zhao, Peng, et al.
Publicado: (2020)

Controlling Mesenchyme Tissue Remodeling via Spatial Arrangement of Mechanical Constraints
por: Winston, Tackla S., et al.
Publicado: (2022)

Perspective: Challenges Presented for Regeneration of Heterogeneous Musculoskeletal Tissues that Normally Develop in Unique Biomechanical Environments
por: Hart, David A., et al.
Publicado: (2021)

Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry
por: Singh, Sumit K., et al.
Publicado: (2022)

A Static Area Coverage Algorithm for Heterogeneous AUV Group Based on Biological Competition Mechanism
por: Guo, Xuan, et al.
Publicado: (2022)

A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects
por: Wang, Lingjun, et al.
Publicado: (2022)

Dissecting insect cell heterogeneity during influenza VLP production using single-cell transcriptomics
por: Silvano, Marco, et al.
Publicado: (2023)

Gene-Focused Networks Underlying Phenotypic Convergence in a Systematically Phenotyped Cohort With Heterogeneous Intellectual Disability
por: Wang, Yan, et al.
Publicado: (2020)

Probing Single-Cell Macrophage Polarization and Heterogeneity Using Thermo-Reversible Hydrogels in Droplet-Based Microfluidics
por: Tiemeijer, B. M., et al.
Publicado: (2021)

Calibration of a Heterogeneous Brain Model Using a Subject-Specific Inverse Finite Element Approach
por: Giudice, J. Sebastian, et al.
Publicado: (2021)

Dynamic Spatial Tuning Patterns of Shoulder Muscles with Volunteers in a Driving Posture
por: Fice, Jason B., et al.
Publicado: (2021)

A Low Cost Implantation Model in the Rat That Allows a Spatial Assessment of Angiogenesis
por: Slezak, Paul, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_t3mfnkgfsuh6toqd1fqlb9rq3a