560G>A (rs4986782) (R187Q) Single Nucleotide Polymorphism in Arylamine N-Acetyltransferase 1 Increases Affinity for the Aromatic Amine Carcinogens 4-Aminobiphenyl and N-Hydroxy-4-Aminobiphenyl: Implications for Cancer Risk Assessment

Human arylamine N-acetyltransferase 1 (NAT1) catalyzes the N-acetylation of arylamine carcinogens such as 4-aminobiphenyl (ABP), and following N-hydroxylation, the O-acetylation of N-hydroxy-arylamine carcinogens such as N-hydroxy-ABP (N-OH-ABP). Genetic polymorphisms in NAT1 are linked to cancer su...

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Detalles Bibliográficos
Autores principales: Doll, Mark A., Hein, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902414/
https://www.ncbi.nlm.nih.gov/pubmed/35273499
http://dx.doi.org/10.3389/fphar.2022.820082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902414/
https://www.ncbi.nlm.nih.gov/pubmed/35273499
http://dx.doi.org/10.3389/fphar.2022.820082

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