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Extracellular Concentration of L-Cystine Determines the Sensitivity to System x(c)(-) Inhibitors
Targeting the cystine/glutamate exchange transporter, system x(c)(-), is a promising anticancer strategy that induces ferroptosis, which is a distinct form of cell death mediated by iron-dependent lipid peroxidation. The concentration of L-cystine in culture medium is higher than the physiological l...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Korean Society of Applied Pharmacology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902454/ https://www.ncbi.nlm.nih.gov/pubmed/34667132 http://dx.doi.org/10.4062/biomolther.2021.105 |