Early IFN-β administration protects cigarette smoke exposed mice against lethal influenza virus infection without increasing lung inflammation

During influenza A virus (IAV) infection, it is unclear whether type I interferons (IFNs) have defensive antiviral effects or contribute to immunopathology in smokers. We treated nonsmoking (NS) and cigarette smoke (CS)-exposed mice intranasally with early (prophylactic) or late (therapeutic) IFN-β....

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Detalles Bibliográficos
Autores principales: Wu, Wenxin, Tian, Lili, Zhang, Wei, Booth, J. Leland, Ritchey, Jerry William, Wu, Shuhua, Xu, Chao, Brown, Brent R., Metcalf, Jordan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902729/
https://www.ncbi.nlm.nih.gov/pubmed/35260752
http://dx.doi.org/10.1038/s41598-022-08066-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902729/
https://www.ncbi.nlm.nih.gov/pubmed/35260752
http://dx.doi.org/10.1038/s41598-022-08066-7

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