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An Approach to Modify 14-Membered Lactone Macrolide Antibiotic Scaffolds
[Image: see text] A ketolide derivative with (12R)-configuration was obtained via a novel ketene acetal in acidic conditions. The structure of this atypical β-keto ketene acetal intermediate within the macrocyclic system has been determined by NMR and X-ray methods. The use of basic conditions at an...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902751/ https://www.ncbi.nlm.nih.gov/pubmed/35020381 http://dx.doi.org/10.1021/acs.joc.1c02799 |