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Chronic corticosterone disrupts the circadian rhythm of CRH expression and m(6)A RNA methylation in the chicken hypothalamus

BACKGROUND: Corticotropin-releasing hormone (CRH), the major secretagogue of the hypothalamic-pituitary-adrenal (HPA) axis, is intricately intertwined with the clock genes to regulate the circadian rhythm of various body functions. N6-methyladenosine (m(6)A) RNA methylation is involved in the regula...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Han, Wanwan, Zhang, Aijia, Zhao, Mindie, Cong, Wei, Jia, Yimin, Wang, Deyun, Zhao, Ruqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902767/
https://www.ncbi.nlm.nih.gov/pubmed/35255992
http://dx.doi.org/10.1186/s40104-022-00677-4