Flipped Over U: Structural Basis for dsRNA Cleavage by the SARS-CoV-2 Endoribonuclease

Coronaviruses generate double-stranded (ds) RNA intermediates during viral replication that can activate host immune sensors. To evade activation of the host pattern recognition receptor MDA5, coronaviruses employ Nsp15, which is uridine-specific endoribonuclease. Nsp15 is proposed to associate with...

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Detalles Bibliográficos
Autores principales: Frazier, Meredith N., Wilson, Isha M., Krahn, Juno M., Butay, Kevin John, Dillard, Lucas B., Borgnia, Mario J., Stanley, Robin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902873/
https://www.ncbi.nlm.nih.gov/pubmed/35262076
http://dx.doi.org/10.1101/2022.03.02.480688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902873/
https://www.ncbi.nlm.nih.gov/pubmed/35262076
http://dx.doi.org/10.1101/2022.03.02.480688

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