Cargando…

Energy landscape of the SARS-CoV-2 reveals extensive conformational heterogeneity

Cryo-electron microscopy (cryo-EM) has produced a number of structural models of the SARS-CoV-2 spike, already prompting biomedical outcomes. However, these reported models and their associated electrostatic potential maps represent an unknown admixture of conformations stemming from the underlying...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mashayekhi, Ghoncheh, Vant, John, Polavarapu, Abhigna, Ourmazd, Abbas, Singharoy, Abhishek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902891/ https://www.ncbi.nlm.nih.gov/pubmed/35284830 http://dx.doi.org/10.1016/j.crstbi.2022.02.001

Ejemplares similares

Energy landscapes from cryo-EM snapshots: a benchmarking study
por: Dsouza, Raison, et al.
Publicado: (2023)

Retrieving functional pathways of biomolecules from single-particle snapshots
por: Dashti, Ali, et al.
Publicado: (2020)

Selecting XFEL single-particle snapshots by geometric machine learning
por: Cruz-Chú, Eduardo R., et al.
Publicado: (2021)

Conformations of macromolecules and their complexes from heterogeneous datasets
por: Schwander, P., et al.
Publicado: (2014)

A glycan gate controls opening of the SARS-CoV-2 spike protein
por: Sztain, Terra, et al.
Publicado: (2021)

A glycan gate controls opening of the SARS-CoV-2 spike protein
por: Sztain, Terra, et al.
Publicado: (2021)

Extensive Conformational Heterogeneity within Protein Cores
por: Bowman, Gregory R., et al.
Publicado: (2014)

Total predicted MHC-I epitope load is inversely associated with population mortality from SARS-CoV-2
por: Wilson, Eric A., et al.
Publicado: (2021)

Conformational ensemble of the NSP1 CTD in SARS-CoV-2: Perspectives from the free energy landscape
por: Dutta, Pallab, et al.
Publicado: (2023)

Nanopore tweezers measurements of RecQ conformational changes reveal the energy landscape of helicase motion
por: Craig, Jonathan M, et al.
Publicado: (2022)

Overall energy conversion efficiency of a photosynthetic vesicle
por: Sener, Melih, et al.
Publicado: (2016)

The heterogeneous energy landscape expression of KWW relaxation
por: Wu, J. H., et al.
Publicado: (2016)

Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes
por: Mielczarek, Olga, et al.
Publicado: (2023)

Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers
por: Neupane, Krishna, et al.
Publicado: (2021)

Extensive transcriptional heterogeneity revealed by isoform profiling
por: Pelechano, Vicent, et al.
Publicado: (2013)

Erratum: The heterogeneous energy landscape expression of KWW relaxation
por: Wu, J. H., et al.
Publicado: (2016)

Dynamic Energy Landscapes of Riboswitches Help Interpret Conformational Rearrangements and Function
por: Quarta, Giulio, et al.
Publicado: (2012)

The Effect of Tensile Stress on the Conformational Free Energy Landscape of Disulfide Bonds
por: Anjukandi, Padmesh, et al.
Publicado: (2014)

Impact of Conformational Substates and Energy Landscapes on Understanding Hemoglobin Kinetics and Function
por: Eaton, William A.
Publicado: (2021)

Conformational landscape of the yeast SAGA complex as revealed by cryo-EM
por: Vasyliuk, Diana, et al.
Publicado: (2022)

Evaluation of Subclinical Extension of Basal Cell Carcinoma
por: Beiraghi Toosi, Arash, et al.
Publicado: (2017)

Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms
por: Stuchell-Brereton, Melissa D., et al.
Publicado: (2023)

The complete conformational free energy landscape of β-xylose reveals a two-fold catalytic itinerary for β-xylanases
por: Iglesias-Fernández, Javier, et al.
Publicado: (2015)

Conformational Heterogeneity and Interchain Percolation Revealed in an Amorphous Conjugated Polymer
por: Ziolek, Robert M., et al.
Publicado: (2022)

Landscapes of SARS-CoV-2-reactive CD8(+) T cells: heterogeneity of host immune responses against SARS-CoV-2
por: Koh, June-Young, et al.
Publicado: (2021)

Preface for Special Issue on Biology with X-ray Lasers 2
por: Ourmazd, Abbas
Publicado: (2015)

An Estimate of the Numbers and Density of Low-Energy Structures (or Decoys) in the Conformational Landscape of Proteins
por: Vadivel, Kanagasabai, et al.
Publicado: (2009)

Enhanced and effective conformational sampling of protein molecular systems for their free energy landscapes
por: Higo, Junichi, et al.
Publicado: (2012)

Mapping transiently formed and sparsely populated conformations on a complex energy landscape
por: Wang, Yong, et al.
Publicado: (2016)

Conformational Dynamics Govern the Free-Energy Landscape of a Membrane-Interacting Protein
por: Frotscher, Erik, et al.
Publicado: (2018)

Exploring conformational preferences of proteins: ionic liquid effects on the energy landscape of avidin
por: Shmool, Talia A., et al.
Publicado: (2020)

The Heterogeneous Landscape and Early Evolution of Pathogen-Associated CpG Dinucleotides in SARS-CoV-2
por: Di Gioacchino, Andrea, et al.
Publicado: (2021)

Evolutionary divergence in the conformational landscapes of tyrosine vs serine/threonine kinases
por: Gizzio, Joan, et al.
Publicado: (2022)

An extended conformation of SARS-CoV-2 main protease reveals allosteric targets
por: Sun, Zengchao, et al.
Publicado: (2022)

To knot or not to knot: Multiple conformations of the SARS-CoV-2 frameshifting RNA element
por: Schlick, Tamar, et al.
Publicado: (2021)

Conformal extensions of the Standard Model
por: Lindner, Manfred
Publicado: (2019)

Activation Pathways and Free Energy Landscapes of the SARS-CoV-2 Spike Protein
por: Wu, Yichao, et al.
Publicado: (2021)

Pandemic-scale phylogenomics reveals the SARS-CoV-2 recombination landscape
por: Turakhia, Yatish, et al.
Publicado: (2022)

Revealing a Hidden Intermediate of Rotatory Catalysis with X-ray Crystallography and Molecular Simulations
por: Shekhar, Mrinal, et al.
Publicado: (2022)

Delineating the RAS Conformational Landscape
por: Parker, Mitchell I., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5had02r0r6nkgauo7mre4adl5q