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TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4(+) T Cells to T(reg)

CD4(+) T lymphocytes are crucial for controlling a range of innate and adaptive immune effectors. For CD8(+) cytotoxic T lymphocyte (CTL) responses, CD4(+) T cells can function as helpers (T(H)) to amplify magnitude and functionality or as regulatory cells (T(reg)) capable of profound inhibition. It...

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Detalles Bibliográficos
Autores principales: Dolina, Joseph S., Lee, Joey, Griswold, Ryan Q., Labarta-Bajo, Lara, Kannan, Sumetha, Greenbaum, Jason A., El Idrissi, Nawal Bahia, Pont, Margot J., Croft, Michael, Schoenberger, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903023/
https://www.ncbi.nlm.nih.gov/pubmed/32268093
http://dx.doi.org/10.1016/j.celrep.2020.01.040