Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversity

The fate of tissue-resident memory CD4 T cells (Trm) has been incompletely investigated. Here we show that intranasal, but not parenteral, immunization with CTA1-3M2e-DD stimulated M2e-specific Th17 Trm cells, which conferred strong protection against influenza virus infection in the lung. These cel...

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Detalles Bibliográficos
Autores principales: Omokanye, Ajibola, Ong, Li Ching, Lebrero-Fernandez, Cristina, Bernasconi, Valentina, Schön, Karin, Strömberg, Anneli, Bemark, Mats, Saelens, Xavier, Czarnewski, Paulo, Lycke, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903128/
https://www.ncbi.nlm.nih.gov/pubmed/35260804
http://dx.doi.org/10.1038/s41385-022-00497-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903128/
https://www.ncbi.nlm.nih.gov/pubmed/35260804
http://dx.doi.org/10.1038/s41385-022-00497-9

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