Relaxing the restricted structural dynamics in the human hepatitis B virus RNA encapsidation signal enables replication initiation in vitro

Hepadnaviruses, including hepatitis B virus (HBV) as a major human pathogen, replicate their tiny 3 kb DNA genomes by capsid-internal protein-primed reverse transcription of a pregenomic (pg) RNA. Initiation requires productive binding of the viral polymerase, P protein, to a 5´ proximal bipartite s...

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Detalles Bibliográficos
Autores principales: Dörnbrack, Katharina, Beck, Jürgen, Nassal, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903280/
https://www.ncbi.nlm.nih.gov/pubmed/35259189
http://dx.doi.org/10.1371/journal.ppat.1010362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903280/
https://www.ncbi.nlm.nih.gov/pubmed/35259189
http://dx.doi.org/10.1371/journal.ppat.1010362

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