Identifying pathways regulating the oncogenic p53 family member ΔNp63 provides therapeutic avenues for squamous cell carcinoma

BACKGROUND: ΔNp63 overexpression is a common event in squamous cell carcinoma (SCC) that contributes to tumorigenesis, making ΔNp63 a potential target for therapy. METHODS: We created inducible TP63-shRNA cells to study the effects of p63-depletion in SCC cell lines and non-malignant HaCaT keratinoc...

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Detalles Bibliográficos
Autores principales: Pokorna, Zuzana, Vyslouzil, Jan, Vojtesek, Borivoj, Coates, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903560/
https://www.ncbi.nlm.nih.gov/pubmed/35196980
http://dx.doi.org/10.1186/s11658-022-00323-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903560/
https://www.ncbi.nlm.nih.gov/pubmed/35196980
http://dx.doi.org/10.1186/s11658-022-00323-x

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