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LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants
BACKGROUND: Tbr1 encodes a T-box transcription factor and is considered a high confidence autism spectrum disorder (ASD) gene. Tbr1 is expressed in the postmitotic excitatory neurons of the deep neocortical layers 5 and 6. Postnatally and neonatally, Tbr1 conditional mutants (CKOs) have immature den...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903688/ https://www.ncbi.nlm.nih.gov/pubmed/35123407 http://dx.doi.org/10.1186/s11689-022-09421-5 |