ROR2 increases the chemoresistance of melanoma by regulating p53 and Bcl2-family proteins via ERK hyperactivation

BACKGROUND: ROR2 is a tyrosine-kinase receptor whose expression is dysregulated in many human diseases. In cancer, ROR2 stimulates proliferation, survival, migration, and metastasis, and is associated with more aggressive tumor stages. The purpose of this work is to study the role of ROR2 in the che...

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Detalles Bibliográficos
Autores principales: Castro, María Victoria, Barbero, Gastón Alexis, Máscolo, Paula, Ramos, Rocío, Quezada, María Josefina, Lopez-Bergami, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903712/
https://www.ncbi.nlm.nih.gov/pubmed/35260073
http://dx.doi.org/10.1186/s11658-022-00327-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903712/
https://www.ncbi.nlm.nih.gov/pubmed/35260073
http://dx.doi.org/10.1186/s11658-022-00327-7

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