DNA methyltransferase 1 inhibits microRNA-497 and elevates GPRC5A expression to promote chemotherapy resistance and metastasis in breast cancer

BACKGROUND: Abnormal DNA methylation of tumor suppressor gene promoter has been found in breast cancer. Therefore, the current study set out to explore how DNA methyltransferase 1 (DNMT1) affects breast cancer through mediating miR-497/GPRC5A axis. METHODS: After loss and gain-of-function approaches...

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Detalles Bibliográficos
Autores principales: Liu, Yaobang, Bai, Zhengyang, Chai, Dahai, Gao, Yali, Li, Ting, Ma, Yinling, Li, Jinping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903738/
https://www.ncbi.nlm.nih.gov/pubmed/35255904
http://dx.doi.org/10.1186/s12935-022-02466-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903738/
https://www.ncbi.nlm.nih.gov/pubmed/35255904
http://dx.doi.org/10.1186/s12935-022-02466-5

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