PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II

Intrahepatic cholangiocarcinoma (ICC) contains abundant myofibroblasts derived from hepatic stellate cells (HSCs) through an activation process mediated by TGF-β. To determine the role of programmed death-ligand 1 (PD-L1) in myofibroblastic activation of HSCs, we disrupted PD-L1 of HSCs by shRNA or...

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Detalles Bibliográficos
Autores principales: Sun, Liankang, Wang, Yuanguo, Wang, Xianghu, Navarro-Corcuera, Amaia, Ilyas, Sumera, Jalan-Sakrikar, Nidhi, Gan, Can, Tu, Xinyi, Shi, Yu, Tu, Kangsheng, Liu, Qingguang, Lou, Zhenkun, Dong, Haidong, Sharpe, Arlene H., Shah, Vijay H., Kang, Ningling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903892/
https://www.ncbi.nlm.nih.gov/pubmed/35139382
http://dx.doi.org/10.1016/j.celrep.2022.110349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903892/
https://www.ncbi.nlm.nih.gov/pubmed/35139382
http://dx.doi.org/10.1016/j.celrep.2022.110349

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