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Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects

Although providing long-lasting immunity, smallpox vaccination was associated with local and systemic reactions and rarely with severe complications, including progressive vaccinia and postvaccinia encephalitis. As the Dryvax smallpox vaccine consists of a population of variants, we investigated a p...

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Detalles Bibliográficos
Autores principales: Liu, Ruikang, Americo, Jeffrey L., Earl, Patricia L., Villani, Jack, Cotter, Catherine A., Moss, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903894/
https://www.ncbi.nlm.nih.gov/pubmed/35189701
http://dx.doi.org/10.1128/mbio.00102-22