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Circulating Tumor DNA Mutations in Progressive Gastrointestinal Stromal Tumors Identify Biomarkers of Treatment Resistance and Uncover Potential Therapeutic Strategies

Liquid biopsy circulating tumor DNA (ctDNA)-based approaches may represent a non-invasive means for molecular interrogation of gastrointestinal stromal tumors (GISTs). We deployed a customized 29-gene Archer(®) LiquidPlex™ targeted panel on 64 plasma samples from 46 patients. The majority were known...

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Detalles Bibliográficos
Autores principales: Ko, Tun Kiat, Lee, Elizabeth, Ng, Cedric Chuan-Young, Yang, Valerie Shiwen, Farid, Mohamad, Teh, Bin Tean, Chan, Jason Yongsheng, Somasundaram, Nagavalli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904145/
https://www.ncbi.nlm.nih.gov/pubmed/35273917
http://dx.doi.org/10.3389/fonc.2022.840843