Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing

The mechanism underlying unwanted structural variations induced by CRISPR-Cas9 remains poorly understood, and no effective strategy is available to inhibit the generation of these byproducts. Here we find that the generation of a high level of translocations is dependent on repeated cleavage at the...

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Detalles Bibliográficos
Autores principales: Yin, Jianhang, Lu, Rusen, Xin, Changchang, Wang, Yuhong, Ling, Xinyu, Li, Dong, Zhang, Weiwei, Liu, Mengzhu, Xie, Wutao, Kong, Lingyun, Si, Wen, Wei, Ping, Xiao, Bingbing, Lee, Hsiang-Ying, Liu, Tao, Hu, Jiazhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904484/
https://www.ncbi.nlm.nih.gov/pubmed/35260581
http://dx.doi.org/10.1038/s41467-022-28900-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904484/
https://www.ncbi.nlm.nih.gov/pubmed/35260581
http://dx.doi.org/10.1038/s41467-022-28900-w

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