Engineered Campylobacter jejuni Cas9 variant with enhanced activity and broader targeting range

The RNA-guided DNA endonuclease Cas9 is a versatile genome-editing tool. However, the molecular weight of the commonly used Streptococcus pyogenes Cas9 is relatively large. Consequently, its gene cannot be efficiently packaged into an adeno-associated virus vector, thereby limiting its applications...

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Detalles Bibliográficos
Autores principales: Nakagawa, Ryoya, Ishiguro, Soh, Okazaki, Sae, Mori, Hideto, Tanaka, Mamoru, Aburatani, Hiroyuki, Yachie, Nozomu, Nishimasu, Hiroshi, Nureki, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904486/
https://www.ncbi.nlm.nih.gov/pubmed/35260779
http://dx.doi.org/10.1038/s42003-022-03149-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904486/
https://www.ncbi.nlm.nih.gov/pubmed/35260779
http://dx.doi.org/10.1038/s42003-022-03149-7

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