Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth

NEMO/IKKβ complex is a central regulator of NF-κB signaling pathway, its dissociation has been considered to be an attractive therapeutic target. Herein, using a combined strategy of molecular pharmacological phenotyping, proteomics and bioinformatics analysis, Shikonin (SHK) is identified as a pote...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Zhenlong, Gao, Jian, Zhang, Xiaolei, Peng, Yulin, Wei, Wenlong, Xu, Jianrong, Li, Zhenwei, Wang, Chao, Zhou, Meirong, Tian, Xiangge, Feng, Lei, Huo, Xiaokui, Liu, Min, Ye, Mingliang, Guo, De-an, Ma, Xiaochi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904520/
https://www.ncbi.nlm.nih.gov/pubmed/35260565
http://dx.doi.org/10.1038/s41392-022-00888-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904520/
https://www.ncbi.nlm.nih.gov/pubmed/35260565
http://dx.doi.org/10.1038/s41392-022-00888-1

Ejemplares similares