A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model

Pre-erythrocytic malaria vaccines that induce high-titer, durable antibody responses can potentially provide protection from infection. Here, we engineered a virus-like particle (VLP)-based vaccine targeting a recently described vulnerable epitope at the N-terminus of the central repeat region of th...

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Detalles Bibliográficos
Autores principales: Jelínková, Lucie, Flores-Garcia, Yevel, Shapiro, Sarah, Roberts, Bryce T., Petrovsky, Nikolai, Zavala, Fidel, Chackerian, Bryce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904524/
https://www.ncbi.nlm.nih.gov/pubmed/35260593
http://dx.doi.org/10.1038/s41541-022-00457-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904524/
https://www.ncbi.nlm.nih.gov/pubmed/35260593
http://dx.doi.org/10.1038/s41541-022-00457-1

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