A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model

Pre-erythrocytic malaria vaccines that induce high-titer, durable antibody responses can potentially provide protection from infection. Here, we engineered a virus-like particle (VLP)-based vaccine targeting a recently described vulnerable epitope at the N-terminus of the central repeat region of th...

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Autores principales: Jelínková, Lucie, Flores-Garcia, Yevel, Shapiro, Sarah, Roberts, Bryce T., Petrovsky, Nikolai, Zavala, Fidel, Chackerian, Bryce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904524/
https://www.ncbi.nlm.nih.gov/pubmed/35260593
http://dx.doi.org/10.1038/s41541-022-00457-1
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author Jelínková, Lucie
Flores-Garcia, Yevel
Shapiro, Sarah
Roberts, Bryce T.
Petrovsky, Nikolai
Zavala, Fidel
Chackerian, Bryce
author_facet Jelínková, Lucie
Flores-Garcia, Yevel
Shapiro, Sarah
Roberts, Bryce T.
Petrovsky, Nikolai
Zavala, Fidel
Chackerian, Bryce
author_sort Jelínková, Lucie
collection PubMed
description Pre-erythrocytic malaria vaccines that induce high-titer, durable antibody responses can potentially provide protection from infection. Here, we engineered a virus-like particle (VLP)-based vaccine targeting a recently described vulnerable epitope at the N-terminus of the central repeat region of the Plasmodium falciparum circumsporozoite protein that is recognized by the potently inhibitory monoclonal antibody L9 and show that immunization with L9 VLPs induces strong antibody responses that provide protection from blood-stage malaria in a mouse infection model.
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spelling pubmed-89045242022-03-23 A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model Jelínková, Lucie Flores-Garcia, Yevel Shapiro, Sarah Roberts, Bryce T. Petrovsky, Nikolai Zavala, Fidel Chackerian, Bryce NPJ Vaccines Brief Communication Pre-erythrocytic malaria vaccines that induce high-titer, durable antibody responses can potentially provide protection from infection. Here, we engineered a virus-like particle (VLP)-based vaccine targeting a recently described vulnerable epitope at the N-terminus of the central repeat region of the Plasmodium falciparum circumsporozoite protein that is recognized by the potently inhibitory monoclonal antibody L9 and show that immunization with L9 VLPs induces strong antibody responses that provide protection from blood-stage malaria in a mouse infection model. Nature Publishing Group UK 2022-03-08 /pmc/articles/PMC8904524/ /pubmed/35260593 http://dx.doi.org/10.1038/s41541-022-00457-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Jelínková, Lucie
Flores-Garcia, Yevel
Shapiro, Sarah
Roberts, Bryce T.
Petrovsky, Nikolai
Zavala, Fidel
Chackerian, Bryce
A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model
title A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model
title_full A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model
title_fullStr A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model
title_full_unstemmed A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model
title_short A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model
title_sort vaccine targeting the l9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904524/
https://www.ncbi.nlm.nih.gov/pubmed/35260593
http://dx.doi.org/10.1038/s41541-022-00457-1
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