Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling

Established models of ternary complex formation between hormone, G protein coupled receptor (GPCR), and G protein assume that all interactions occur under equilibrium conditions. However, recent studies have established that the lifetimes of these interactions are comparable to the duration of hormo...

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Detalles Bibliográficos
Autores principales: Culhane, Kelly J., Gupte, Tejas M., Madhugiri, Indrani, Gadgil, Chetan J., Sivaramakrishnan, Sivaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904551/
https://www.ncbi.nlm.nih.gov/pubmed/35260563
http://dx.doi.org/10.1038/s41467-022-28789-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904551/
https://www.ncbi.nlm.nih.gov/pubmed/35260563
http://dx.doi.org/10.1038/s41467-022-28789-5

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