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Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling

Established models of ternary complex formation between hormone, G protein coupled receptor (GPCR), and G protein assume that all interactions occur under equilibrium conditions. However, recent studies have established that the lifetimes of these interactions are comparable to the duration of hormo...

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Detalles Bibliográficos
Autores principales:	Culhane, Kelly J., Gupte, Tejas M., Madhugiri, Indrani, Gadgil, Chetan J., Sivaramakrishnan, Sivaraj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904551/ https://www.ncbi.nlm.nih.gov/pubmed/35260563 http://dx.doi.org/10.1038/s41467-022-28789-5

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