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Chronic Diclofenac Exposure Increases Mitochondrial Oxidative Stress, Inflammatory Mediators, and Cardiac Dysfunction

PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among one of the most commonly prescribed medications for pain and inflammation. Diclofenac (DIC) is a commonly prescribed NSAID that is known to increase the risk of cardiovascular diseases. However, the mechanisms underlying its cardiotoxi...

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Detalles Bibliográficos
Autores principales: Thai, Phung N., Ren, Lu, Xu, Wilson, Overton, James, Timofeyev, Valeriy, Nader, Carol E., Haddad, Michael, Yang, Jun, Gomes, Aldrin V, Hammock, Bruce D., Chiamvimonvat, Nipavan, Sirish, Padmini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904649/
https://www.ncbi.nlm.nih.gov/pubmed/34499283
http://dx.doi.org/10.1007/s10557-021-07253-4