Engineering an acetoacetyl-CoA reductase from Cupriavidus necator toward NADH preference under physiological conditions

The coupling of PHB generation with NADH reoxidation is required to generate PHB as a fermentation product. A fundamental trait to accomplish this feature is to express a functional NADH-preferring acetoacetyl-CoA reductase, engaged in PHB accumulation. One way to obtain such a reductase is by engin...

Descripción completa

Detalles Bibliográficos
Autores principales: Olavarria, Karel, Pijman, Yared O., Cabrera, Ricardo, van Loosdrecht, Mark C. M., Wahl, S. Aljoscha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904767/
https://www.ncbi.nlm.nih.gov/pubmed/35260659
http://dx.doi.org/10.1038/s41598-022-07663-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904767/
https://www.ncbi.nlm.nih.gov/pubmed/35260659
http://dx.doi.org/10.1038/s41598-022-07663-w

Ejemplares similares