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Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress

The chronic inflammatory process that characterizes inflammatory bowel diseases (IBD) is mainly driven by T-cell response to microbial and environmental antigens. Psychological stress is a potential trigger of clinical flares of IBD, and sphingosine-1-phosphate (S1P) is involved in T-cell recruitmen...

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Detalles Bibliográficos
Autores principales: Martín-Hernández, David, Gutiérrez, Irene L., González-Prieto, Marta, MacDowell, Karina S., Robledo-Montaña, Javier, Tendilla-Beltrán, Hiram, Calleja-Rodríguez, Natalia, Bris, Álvaro G., Ulecia-Morón, Cristina, Moreno, Beatriz, Caso, Javier R., García-Bueno, Borja, Rodrigues-Mascarenhas, Sandra, Marín-Jiménez, Ignacio, Leza, Juan Carlos, Menchén, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904788/
https://www.ncbi.nlm.nih.gov/pubmed/35260749
http://dx.doi.org/10.1038/s41598-022-08011-8