Differential recognition of canonical NF-κB dimers by Importin α3

Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. In unstimulated cells, p50/p65 is retained by the inhibitor IκBα in the cytoplasm that masks the p65-nuclear localization sequence (NLS). Upon activation, p50/p65 is translocated into the nucleus by the adapter import...

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Detalles Bibliográficos
Autores principales: Florio, Tyler J., Lokareddy, Ravi K., Yeggoni, Daniel P., Sankhala, Rajeshwer S., Ott, Connor A., Gillilan, Richard E., Cingolani, Gino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904830/
https://www.ncbi.nlm.nih.gov/pubmed/35260573
http://dx.doi.org/10.1038/s41467-022-28846-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904830/
https://www.ncbi.nlm.nih.gov/pubmed/35260573
http://dx.doi.org/10.1038/s41467-022-28846-z

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