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Differential recognition of canonical NF-κB dimers by Importin α3

Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. In unstimulated cells, p50/p65 is retained by the inhibitor IκBα in the cytoplasm that masks the p65-nuclear localization sequence (NLS). Upon activation, p50/p65 is translocated into the nucleus by the adapter import...

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Detalles Bibliográficos
Autores principales:	Florio, Tyler J., Lokareddy, Ravi K., Yeggoni, Daniel P., Sankhala, Rajeshwer S., Ott, Connor A., Gillilan, Richard E., Cingolani, Gino
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904830/ https://www.ncbi.nlm.nih.gov/pubmed/35260573 http://dx.doi.org/10.1038/s41467-022-28846-z

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