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The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer

SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione synthesis; a process that protects cells from oxidative stress and is, therefore, critical to cell growth, proli...

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Detalles Bibliográficos
Autores principales:	Jyotsana, Nidhi, Ta, Kenny T., DelGiorno, Kathleen E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904967/ https://www.ncbi.nlm.nih.gov/pubmed/35280777 http://dx.doi.org/10.3389/fonc.2022.858462

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