Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia

BRD4 plays a key role in the regulation of gene transcription and has been identified as an attractive target for cancer treatment. In this study, we designed 26 new compounds by modifying 3-ethyl-benzo[d]isoxazole core with sulfonamides. Most compounds exhibited potent BRD4 binding activities with...

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Detalles Bibliográficos
Autores principales: Zhang, Mao-feng, Luo, Xiao-yu, Zhang, Cheng, Wang, Chao, Wu, Xi-shan, Xiang, Qiu-ping, Xu, Yong, Zhang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905034/
https://www.ncbi.nlm.nih.gov/pubmed/35264812
http://dx.doi.org/10.1038/s41401-022-00881-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905034/
https://www.ncbi.nlm.nih.gov/pubmed/35264812
http://dx.doi.org/10.1038/s41401-022-00881-y

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