An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

The HNF1α(p291fsinsC) truncation is the most common mutation associated with maturity-onset diabetes of the young 3 (MODY3). Although shown to impair HNF1α signaling, the mechanism by which HNF1α(p291fsinsC) causes MODY3 is not fully understood. Here we use MODY3 patient and CRISPR/Cas9-engineered h...

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Detalles Bibliográficos
Autores principales: Cujba, Ana-Maria, Alvarez-Fallas, Mario E., Pedraza-Arevalo, Sergio, Laddach, Anna, Shepherd, Maggie H., Hattersley, Andrew T., Watt, Fiona M., Sancho, Rocio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905088/
https://www.ncbi.nlm.nih.gov/pubmed/35235779
http://dx.doi.org/10.1016/j.celrep.2022.110425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905088/
https://www.ncbi.nlm.nih.gov/pubmed/35235779
http://dx.doi.org/10.1016/j.celrep.2022.110425

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