Overexpression of ABCB1 Associated With the Resistance to the KRAS-G12C Specific Inhibitor ARS-1620 in Cancer Cells

The KRAS-G12C inhibitor ARS-1620, is a novel specific covalent inhibitor of KRAS-G12C, possessing a strong targeting inhibitory effect on KRAS-G12C mutant tumors. Overexpression of ATP-binding cassette super-family B member 1 (ABCB1/P-gp) is one of the pivotal factors contributing to multidrug resis...

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Detalles Bibliográficos
Autores principales: Dong, Xing-Duo, Zhang, Meng, Cai, Chao-Yun, Teng, Qiu-Xu, Wang, Jing-Quan, Fu, Yi-Ge, Cui, Qingbin, Patel, Ketankumar, Wang, Dong-Tao, Chen, Zhe-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905313/
https://www.ncbi.nlm.nih.gov/pubmed/35281897
http://dx.doi.org/10.3389/fphar.2022.843829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905313/
https://www.ncbi.nlm.nih.gov/pubmed/35281897
http://dx.doi.org/10.3389/fphar.2022.843829

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