Developing crosslinkers specific for epimerization domain in NRPS initiation modules to evaluate mechanism

Nonribosomal peptide synthetases (NRPSs) are complex multi-modular enzymes containing catalytic domains responsible for the loading and incorporation of amino acids into natural products. These unique molecular factories can produce peptides with nonproteinogenic d-amino acids in which the epimeriza...

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Detalles Bibliográficos
Autores principales: Kim, Woojoo E., Ishikawa, Fumihiro, Re, Rebecca N., Suzuki, Takehiro, Dohmae, Naoshi, Kakeya, Hideaki, Tanabe, Genzoh, Burkart, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905534/
https://www.ncbi.nlm.nih.gov/pubmed/35359491
http://dx.doi.org/10.1039/d2cb00005a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905534/
https://www.ncbi.nlm.nih.gov/pubmed/35359491
http://dx.doi.org/10.1039/d2cb00005a

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