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Developing crosslinkers specific for epimerization domain in NRPS initiation modules to evaluate mechanism

Nonribosomal peptide synthetases (NRPSs) are complex multi-modular enzymes containing catalytic domains responsible for the loading and incorporation of amino acids into natural products. These unique molecular factories can produce peptides with nonproteinogenic d-amino acids in which the epimeriza...

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Detalles Bibliográficos
Autores principales:	Kim, Woojoo E., Ishikawa, Fumihiro, Re, Rebecca N., Suzuki, Takehiro, Dohmae, Naoshi, Kakeya, Hideaki, Tanabe, Genzoh, Burkart, Michael D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905534/ https://www.ncbi.nlm.nih.gov/pubmed/35359491 http://dx.doi.org/10.1039/d2cb00005a

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