Induced cell-autonomous neutropenia systemically perturbs hematopoiesis in Cebpa enhancer-null mice

The transcription factor C/EBPa initiates the neutrophil gene expression program in the bone marrow (BM). Knockouts of the Cebpa gene or its +37kb enhancer in mice show 2 major findings: (1) neutropenia in BM and blood; (2) decrease in long-term hematopoietic stem cell (LT-HSC) numbers. Whether the...

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Detalles Bibliográficos
Autores principales: Avellino, Roberto, Mulet-Lazaro, Roger, Havermans, Marije, Hoogenboezem, Remco, Smeenk, Leonie, Salomonis, Nathan, Schneider, Rebekka K., Rombouts, Elwin, Bindels, Eric, Grimes, Lee, Delwel, Ruud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905702/
https://www.ncbi.nlm.nih.gov/pubmed/34814180
http://dx.doi.org/10.1182/bloodadvances.2021005851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905702/
https://www.ncbi.nlm.nih.gov/pubmed/34814180
http://dx.doi.org/10.1182/bloodadvances.2021005851

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