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Dual-Targeted Self-Assembled DNA Hydrogels Decorated With Multivalent Aptamers Loaded With DOX for Anticancer Therapy

Chemotherapy, as one of the principal modalities for cancer therapy, is limited by its non-specific and inefficient delivery to tumors. To overcome these limitations, we report herein a dual-targeted aptamer-decorated DNA hydrogel system (DTA-H) to achieve efficient, stable, and targeted delivery of...

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Autores principales: Jin, Fangfang, Zeng, Qian, Qian, Husun, Zhang, Dian, Wei, Yu, Wang, Yange, Chai, Chengsen, Cheng, Wei, Ding, Shijia, Chen, Tingmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905714/
https://www.ncbi.nlm.nih.gov/pubmed/35281887
http://dx.doi.org/10.3389/fphar.2022.807498
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author Jin, Fangfang
Zeng, Qian
Qian, Husun
Zhang, Dian
Wei, Yu
Wang, Yange
Chai, Chengsen
Cheng, Wei
Ding, Shijia
Chen, Tingmei
author_facet Jin, Fangfang
Zeng, Qian
Qian, Husun
Zhang, Dian
Wei, Yu
Wang, Yange
Chai, Chengsen
Cheng, Wei
Ding, Shijia
Chen, Tingmei
author_sort Jin, Fangfang
collection PubMed
description Chemotherapy, as one of the principal modalities for cancer therapy, is limited by its non-specific and inefficient delivery to tumors. To overcome these limitations, we report herein a dual-targeted aptamer-decorated DNA hydrogel system (DTA-H) to achieve efficient, stable, and targeted delivery of drugs. Firstly, DNA hydrogel was formed by the rolling circle amplification. By reasonable design, double target and multivalent aptamers were decorated on DNA hydrogel to load DOX. The results confirmed that DTA-H can deliver chemotherapy drugs and aptamer nucleic acids drugs to target cells, inducing degradation of HER2 protein while chemotherapy is synergistic to inhibit HER2-positive breast cancer growth. The proposed drug delivery system has significant potential to achieve efficient, stable, and targeted delivery of drugs and cancer therapy.
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spelling pubmed-89057142022-03-10 Dual-Targeted Self-Assembled DNA Hydrogels Decorated With Multivalent Aptamers Loaded With DOX for Anticancer Therapy Jin, Fangfang Zeng, Qian Qian, Husun Zhang, Dian Wei, Yu Wang, Yange Chai, Chengsen Cheng, Wei Ding, Shijia Chen, Tingmei Front Pharmacol Pharmacology Chemotherapy, as one of the principal modalities for cancer therapy, is limited by its non-specific and inefficient delivery to tumors. To overcome these limitations, we report herein a dual-targeted aptamer-decorated DNA hydrogel system (DTA-H) to achieve efficient, stable, and targeted delivery of drugs. Firstly, DNA hydrogel was formed by the rolling circle amplification. By reasonable design, double target and multivalent aptamers were decorated on DNA hydrogel to load DOX. The results confirmed that DTA-H can deliver chemotherapy drugs and aptamer nucleic acids drugs to target cells, inducing degradation of HER2 protein while chemotherapy is synergistic to inhibit HER2-positive breast cancer growth. The proposed drug delivery system has significant potential to achieve efficient, stable, and targeted delivery of drugs and cancer therapy. Frontiers Media S.A. 2022-02-23 /pmc/articles/PMC8905714/ /pubmed/35281887 http://dx.doi.org/10.3389/fphar.2022.807498 Text en Copyright © 2022 Jin, Zeng, Qian, Zhang, Wei, Wang, Chai, Cheng, Ding and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Jin, Fangfang
Zeng, Qian
Qian, Husun
Zhang, Dian
Wei, Yu
Wang, Yange
Chai, Chengsen
Cheng, Wei
Ding, Shijia
Chen, Tingmei
Dual-Targeted Self-Assembled DNA Hydrogels Decorated With Multivalent Aptamers Loaded With DOX for Anticancer Therapy
title Dual-Targeted Self-Assembled DNA Hydrogels Decorated With Multivalent Aptamers Loaded With DOX for Anticancer Therapy
title_full Dual-Targeted Self-Assembled DNA Hydrogels Decorated With Multivalent Aptamers Loaded With DOX for Anticancer Therapy
title_fullStr Dual-Targeted Self-Assembled DNA Hydrogels Decorated With Multivalent Aptamers Loaded With DOX for Anticancer Therapy
title_full_unstemmed Dual-Targeted Self-Assembled DNA Hydrogels Decorated With Multivalent Aptamers Loaded With DOX for Anticancer Therapy
title_short Dual-Targeted Self-Assembled DNA Hydrogels Decorated With Multivalent Aptamers Loaded With DOX for Anticancer Therapy
title_sort dual-targeted self-assembled dna hydrogels decorated with multivalent aptamers loaded with dox for anticancer therapy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905714/
https://www.ncbi.nlm.nih.gov/pubmed/35281887
http://dx.doi.org/10.3389/fphar.2022.807498
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