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shRNAs targeting mouse Adam10 diminish cell response to proinflammatory stimuli independently of Adam10 silencing

RNA interference is one of the common methods of studying protein functions. In recent years critical reports have emerged indicating that off-target effects may have a much greater impact on RNAi-based analysis than previously assumed. We studied the influence of Adam10 and Adam17 silencing on MC38...

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Detalles Bibliográficos
Autores principales: Czarnek, Maria, Stalińska, Krystyna, Sarad, Katarzyna, Bereta, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905717/
https://www.ncbi.nlm.nih.gov/pubmed/35107128
http://dx.doi.org/10.1242/bio.059092