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Knockdown of CD44 inhibits proliferation, migration and invasion of osteosarcoma cells accompanied by downregulation of cathepsin S

BACKGROUND: Osteosarcoma (OS) is a malignant bone tumour of mesenchymal origin. These tumours are characterised by rich vascularisation, therefore promoting rapid proliferation and facilitating metastasis. CD44 has been reported to be involved in OS, but its role and molecular mechanisms in the path...

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Detalles Bibliográficos
Autores principales: Kong, Lingwei, Ji, Hairu, Gan, Xintian, Cao, Sheng, Li, Zhehong, Jin, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905747/
https://www.ncbi.nlm.nih.gov/pubmed/35264209
http://dx.doi.org/10.1186/s13018-022-03048-x