Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline

Drug isomers may differ in their proarrhythmia risk. An interesting example is the drug sotalol, an antiarrhythmic drug comprising d- and l- enantiomers that both block the hERG cardiac potassium channel and confer differing degrees of proarrhythmic risk. We developed a multi-scale in silico pipelin...

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Detalles Bibliográficos
Autores principales: DeMarco, Kevin R., Yang, Pei-Chi, Singh, Vikrant, Furutani, Kazuharu, Dawson, John R. D., Jeng, Mao-Tsuen, Fettinger, James C., Bekker, Slava, Ngo, Van A., Noskov, Sergei Y., Yarov-Yarovoy, Vladimir, Sack, Jon T., Wulff, Heike, Clancy, Colleen E., Vorobyov, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906354/
https://www.ncbi.nlm.nih.gov/pubmed/34062207
http://dx.doi.org/10.1016/j.yjmcc.2021.05.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906354/
https://www.ncbi.nlm.nih.gov/pubmed/34062207
http://dx.doi.org/10.1016/j.yjmcc.2021.05.015

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