A conserved arginine in NS5 binds genomic 3′ stem–loop RNA for primer-independent initiation of flavivirus RNA replication

The commitment to replicate the RNA genome of flaviviruses without a primer involves RNA–protein interactions that have been shown to include the recognition of the stem–loop A (SLA) in the 5′ untranslated region (UTR) by the nonstructural protein NS5. We show that DENV2 NS5 arginine 888, located wi...

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Detalles Bibliográficos
Autores principales: Wang, Sai, Chan, Kitti Wing Ki, Tan, Min Jie Alvin, Flory, Charlotte, Luo, Dahai, Lescar, Julian, Forwood, Jade K., Vasudevan, Subhash G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906541/
https://www.ncbi.nlm.nih.gov/pubmed/34759006
http://dx.doi.org/10.1261/rna.078949.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906541/
https://www.ncbi.nlm.nih.gov/pubmed/34759006
http://dx.doi.org/10.1261/rna.078949.121

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