Ribosome profiling reveals novel regulation of C9ORF72 GGGGCC repeat-containing RNA translation

GGGGCC (G(4)C(2)) repeat expansion in the first intron of C9ORF72 causes amyotrophic lateral sclerosis and frontotemporal dementia. Repeat-containing RNA is translated into dipeptide repeat (DPR) proteins, some of which are neurotoxic. Using dynamic ribosome profiling, we identified three translatio...

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Detalles Bibliográficos
Autores principales: van ‘t Spijker, Heleen M., Stackpole, Emily E., Almeida, Sandra, Katsara, Olga, Liu, Botao, Shen, Kuang, Schneider, Robert J., Gao, Fen-Biao, Richter, Joel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906550/
https://www.ncbi.nlm.nih.gov/pubmed/34848561
http://dx.doi.org/10.1261/rna.078963.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906550/
https://www.ncbi.nlm.nih.gov/pubmed/34848561
http://dx.doi.org/10.1261/rna.078963.121

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