Causal reasoning over knowledge graphs leveraging drug-perturbed and disease-specific transcriptomic signatures for drug discovery

Network-based approaches are becoming increasingly popular for drug discovery as they provide a systems-level overview of the mechanisms underlying disease pathophysiology. They have demonstrated significant early promise over other methods of biological data representation, such as in target discov...

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Detalles Bibliográficos
Autores principales: Domingo-Fernández, Daniel, Gadiya, Yojana, Patel, Abhishek, Mubeen, Sarah, Rivas-Barragan, Daniel, Diana, Chris W., Misra, Biswapriya B., Healey, David, Rokicki, Joe, Colluru, Viswa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906585/
https://www.ncbi.nlm.nih.gov/pubmed/35213534
http://dx.doi.org/10.1371/journal.pcbi.1009909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906585/
https://www.ncbi.nlm.nih.gov/pubmed/35213534
http://dx.doi.org/10.1371/journal.pcbi.1009909

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