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Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation
Large-scale molecular profiling and genotyping provide a unique opportunity to systematically compare the genetically predicted effects of therapeutic targets on the human metabolome. We firstly constructed genetic risk scores for 8 drug targets on the basis that they primarily modify low-density li...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906647/ https://www.ncbi.nlm.nih.gov/pubmed/35213538 http://dx.doi.org/10.1371/journal.pbio.3001547 |