Cargando…

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation

Large-scale molecular profiling and genotyping provide a unique opportunity to systematically compare the genetically predicted effects of therapeutic targets on the human metabolome. We firstly constructed genetic risk scores for 8 drug targets on the basis that they primarily modify low-density li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Richardson, Tom G., Leyden, Genevieve M., Wang, Qin, Bell, Joshua A., Elsworth, Benjamin, Davey Smith, George, Holmes, Michael V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Methods and Resources
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906647/ https://www.ncbi.nlm.nih.gov/pubmed/35213538 http://dx.doi.org/10.1371/journal.pbio.3001547

Ejemplares similares

In situ characterisation and manipulation of biological systems with Chi.Bio
por: Steel, Harrison, et al.
Publicado: (2020)

Time-varying and tissue-dependent effects of adiposity on leptin levels: A Mendelian randomization study
por: Richardson, Tom G, et al.
Publicado: (2023)

Comparative single-cell transcriptional atlases of Babesia species reveal conserved and species-specific expression profiles
por: Rezvani, Yasaman, et al.
Publicado: (2022)

The use of negative control outcomes in Mendelian randomization to detect potential population stratification
por: Sanderson, Eleanor, et al.
Publicado: (2021)

A lifecourse Mendelian randomization study uncovers age-dependent effects of adiposity on asthma risk
por: Urquijo, Helena, et al.
Publicado: (2023)

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
por: Davies, Neil M, et al.
Publicado: (2018)

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study
por: Richardson, Tom G, et al.
Publicado: (2020)

Metabolic turnover and dynamics of modified ribonucleosides by (13)C labeling
por: Gameiro, Paulo A., et al.
Publicado: (2021)

An immunogenic cell injury module for the single-cell multiplexed activity metabolomics platform to identify promising anti-cancer natural products
por: Balsamo, Joseph A., et al.
Publicado: (2022)

Fully automated leg tracking of Drosophila neurodegeneration models reveals distinct conserved movement signatures
por: Wu, Shuang, et al.
Publicado: (2019)

GC × GC-TOFMS metabolomics analysis identifies elevated levels of plasma sugars and sugar alcohols in diabetic mellitus patients with kidney failure
por: Duangkumpha, Kassaporn, et al.
Publicado: (2022)

Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock
por: Dyar, Kenneth Allen, et al.
Publicado: (2018)

Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation
por: Leyden, Genevieve M., et al.
Publicado: (2022)

Reconstitution of purified membrane protein dimers in lipid nanodiscs with defined stoichiometry and orientation using a split GFP tether
por: Bruguera, Elise S., et al.
Publicado: (2022)

Multivariate phenotype analysis enables genome-wide inference of mammalian gene function
por: Nicholson, George, et al.
Publicado: (2022)

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis
por: Richardson, Tom G., et al.
Publicado: (2020)

A flexible framework for multi-particle refinement in cryo-electron tomography
por: Burt, Alister, et al.
Publicado: (2021)

Protocol for parallel proteomic and metabolomic analysis of mouse intervertebral disc tissues
por: Veras, Matthew A., et al.
Publicado: (2020)

Systematic characterization of photoperiodic gene expression patterns reveals diverse seasonal transcriptional systems in Arabidopsis
por: Leung, Chun Chung, et al.
Publicado: (2023)

FishNET: An automated relational database for zebrafish colony management
por: Cantu Gutierrez, Abiud, et al.
Publicado: (2019)

A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure
por: O’Nunain, Katie, et al.
Publicado: (2022)

Development of a novel mammalian display system for selection of antibodies against membrane proteins
por: Robertson, Nathan, et al.
Publicado: (2021)

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites
por: Boucher, Michael J., et al.
Publicado: (2018)

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
por: Hartwig, Fernando Pires, et al.
Publicado: (2017)

Circadian regulation of the transcriptome in a complex polyploid crop
por: Rees, Hannah, et al.
Publicado: (2022)

Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation
por: Heap, Rachel E, et al.
Publicado: (2021)

Interpreting Mendelian-randomization estimates of the effects of categorical exposures such as disease status and educational attainment
por: Howe, Laurence J, et al.
Publicado: (2021)

Functional Metabolomics Describes the Yeast Biosynthetic Regulome
por: Mülleder, Michael, et al.
Publicado: (2016)

Interpretation of Mendelian randomization using a single measure of an exposure that varies over time
por: Morris, Tim T, et al.
Publicado: (2022)

A framework for assessing selection and misclassification bias in mendelian randomisation studies: an illustrative example between body mass index and covid-19
por: Clayton, Gemma L, et al.
Publicado: (2023)

Tools for assessing quality and risk of bias in Mendelian randomization studies: a systematic review
por: Spiga, Francesca, et al.
Publicado: (2022)

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors
por: Burgess, Stephen, et al.
Publicado: (2015)

Bias in two-sample Mendelian randomization when using heritable covariable-adjusted summary associations
por: Hartwig, Fernando Pires, et al.
Publicado: (2021)

Prediction of drug cocktail effects when the number of measurements is limited
por: Zimmer, Anat, et al.
Publicado: (2017)

An atlas of Caenorhabditis elegans chemoreceptor expression
por: Vidal, Berta, et al.
Publicado: (2018)

Evaluation of e-liquid toxicity using an open-source high-throughput screening assay
por: Sassano, M. Flori, et al.
Publicado: (2018)

The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen–encoding var genes
por: Tonkin-Hill, Gerry Q., et al.
Publicado: (2018)

Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map
por: Smith, Ian, et al.
Publicado: (2017)

The sea cucumber genome provides insights into morphological evolution and visceral regeneration
por: Zhang, Xiaojun, et al.
Publicado: (2017)

Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo
por: Sonzogni, Olmo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_umc8jhkkke09e51cfefrqjc7un