Frequency- and spike-timing-dependent mitochondrial Ca(2+) signaling regulates the metabolic rate and synaptic efficacy in cortical neurons

Mitochondrial activity is crucial for the plasticity of central synapses, but how the firing pattern of pre- and postsynaptic neurons affects the mitochondria remains elusive. We recorded changes in the fluorescence of cytosolic and mitochondrial Ca(2+) indicators in cell bodies, axons, and dendrite...

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Detalles Bibliográficos
Autores principales: Stoler, Ohad, Stavsky, Alexandra, Khrapunsky, Yana, Melamed, Israel, Stutzmann, Grace, Gitler, Daniel, Sekler, Israel, Fleidervish, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906805/
https://www.ncbi.nlm.nih.gov/pubmed/35192454
http://dx.doi.org/10.7554/eLife.74606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906805/
https://www.ncbi.nlm.nih.gov/pubmed/35192454
http://dx.doi.org/10.7554/eLife.74606

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