TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

The membrane protein TREM2 (Triggering Receptor Expressed on Myeloid cells 2) regulates key microglial functions including phagocytosis and chemotaxis. Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD). Because abnormalities in Ca(2+) signaling have be...

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Detalles Bibliográficos
Autores principales: Jairaman, Amit, McQuade, Amanda, Granzotto, Alberto, Kang, You Jung, Chadarevian, Jean Paul, Gandhi, Sunil, Parker, Ian, Smith, Ian, Cho, Hansang, Sensi, Stefano L, Othy, Shivashankar, Blurton-Jones, Mathew, Cahalan, Michael D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906810/
https://www.ncbi.nlm.nih.gov/pubmed/35191835
http://dx.doi.org/10.7554/eLife.73021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906810/
https://www.ncbi.nlm.nih.gov/pubmed/35191835
http://dx.doi.org/10.7554/eLife.73021

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