Protective Effect of Crocin on Immune Checkpoint Inhibitors-Related Myocarditis Through Inhibiting NLRP3 Mediated Pyroptosis in Cardiomyocytes via NF-κB Pathway

PURPOSE: Immune checkpoint inhibitors (ICIs)-related myocarditis is now one of the most critical immune-related adverse effects (irAEs) in tumor immunotherapy, which has raised great concern in cardio-oncology. The pathogenesis involved in cardiac injury remains elusive. Crocin, the main component o...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hui, Lin, Jinyi, Shen, Yihui, Pan, Jianan, Wang, Chunhui, Cheng, Leilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906878/
https://www.ncbi.nlm.nih.gov/pubmed/35282269
http://dx.doi.org/10.2147/JIR.S348464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906878/
https://www.ncbi.nlm.nih.gov/pubmed/35282269
http://dx.doi.org/10.2147/JIR.S348464

Ejemplares similares